I tried edited hotkeys.txt and assigned E to Edit Mesh:
It works while Mesh is already checked in the Options.
However, it would be better if Spine can just auto tick the Mesh checkbox for me if it is not already checked so that I can just select an attachment and press E to enter Mesh Editing mode directly without moving the mouse here an there.
Right now when Mesh is not checked, nothing will happen. (wasted)